UNC45A ELISA Kit for Human(Homo sapiens) | EIAab.comUNC45A ELISA Kit for Human(Homo sapiens)

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Index > Protein center > UNC45A(Gene name) > Human

UNC45A (Gene name),

Protein unc-45 homolog A (Protein name ), UN45A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UNC45A(SMAP1);

Protein name:

Protein unc-45 homolog A(Unc-45A);

Alternative:

Smooth muscle cell-associated protein 1(SMAP-1);GCUNC-45;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.

Function:

Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.

Subcellular Location:

Cytoplasm Cytoplasm perinuclear region Nucleus Predominant in the perinuclear region. Little protein in the nucleus.

Protein Attributes:

Sequence length:

944

Sequence:

50:

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300:

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650:

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944:

MESEMMEILS | VLAKGDHSPV | TRAAAACLDK | AVEYGLIQPN | QDGE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

611219

Pfam:

PF11701

String:

Q9H3U1

SMR:

Q9H3U1

STRING:

9606.ENSP00000407487

KEGG:

hsa:55898

UniGene:

Hs.389461

Pfam:

PF07719

Uniprot:

Q9H3U1

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ELISA Kit for Human Unc-45A

Cat.:

E14842h

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96T

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ELISA Kit for Human Unc-45A

Cat.:

E14842m

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96T

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ELISA Kit for Human Unc-45A

Cat.:

E14842r

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96T

CLIA Kit for Human Unc-45A

Cat.:

U14842r

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Packing:

96T

CLIA Kit for Human Unc-45A

Cat.:

U14842h

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Packing:

96T

CLIA Kit for Human Unc-45A

Cat.:

U14842m

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96T

Polyclonal Antibody for Human Unc-45A

Cat.:

P14842Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Unc-45A

Cat.:

P14842Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Unc-45A

Cat.:

P14842Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Unc-45A

Protein for Human Unc-45A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning and characterization of human smooth muscle cell associated protein-1 (SMAP-1)."
Nishimoto S. , Toyoda H. , Tawara J. , Aoki T. , Komurasaki T.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Heart.
2.

The European IMAGE consortium
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 756-944
tissue: Brain.
tissue: Fetus.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Placenta.
tissue: Testis.
4.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Colon.
tissue: Lung.
tissue: Uterus.
6.

"Cloning, characterization and chromosome mapping of the human SMAP1 gene."
Marcos I. , Borrego S. , Rodriguez de Cordoba S. , Galan J.J. , Antinolo G.
Gene292:167-171(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
7.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-483;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"The solution structure of the tetratricopeptide repeat of human smooth muscle cell associated protein-1."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-06) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-135
13.

"GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."
Chadli A. , Graham J.D. , Abel M.G. , Jackson T.A. , Gordon D.F. , Wood W.M. , Felts S.J. , Horwitz K.B. , Toft D.
Mol. Cell. Biol.26:1722-1730(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PGR; NR3C1 AND HSP90AB1;MUTAGENESIS OF LYS-33; ALA-40; LYS-70 AND ALA-77

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